Last season's runners-up Leeds Rhinos will begin their Cup campaign against Wakefield Trinity Wildcats at Headingley Carnegie Stadium while one of the most mouth-watering ties of the round will see a fierce local derby contested at The BigFellas Stadium, when Featherstone Rovers host their Super League neighbours Castleford Tigers.
Hull FC and Hull KR will welcome Huddersfield Giants and Catalan Dragons, respectively, to East Yorkshire while Widnes Vikings take on St Helens in the only other all-Super League tie.
The ties will be played over the weekend on April 14/15.
The draw for the Challenge Cup Fourth Round in full is:
London Broncos v Dewsbury Rams
Widnes Vikings v St Helens
Leeds Rhinos v Wakefield Trinity Wildcats
Whitehaven v Salford City Reds
Featherstone Rovers v Castleford Tigers
Hull FC v Huddersfield Giants
Wigan Warriors v North Wales Crusaders
Swinton Lions v Gateshead Thunder
Hull KR v Catalan Dragons
Bradford Bulls v Doncaster
South Wales Scorpions v Halifax
York City Knights v Sheffield Eagles
Keighley Cougars v Warrington Wolves
Leigh Centurions v Rochdale Hornets
Oldham v Barrow Raiders
Hunslet Hawks v Batley Bulldogs